Nucleophilic addition reaction: Mechanism, ionisation of carboxylic acids, acidity constants, acidity of acids, structure of carboxylate ions, effect of substituent on acidity, nucleophilic acyl substitution reaction, conversion of acid to acid chloride, esters, amide and anhydride. Role of caboxyl group, comparison of alkyl nucleophilic substitution with acyl nucleophilic substitution.
PATH: PHARMD/PHARMD NOTES/ PHARMD FIRST YEAR NOTES/ ORGANIC CHEMISTRY/ PHARMACEUTICAL ORGANIC CHEMISTRY/NUCLEOPHILIC ADDITION REACTION.