The Knoevenagel reaction is a versatile organic reaction that involves the condensation of an aldehyde or a ketone with an active methylene compound, typically a compound containing a methylene group adjacent to a carbonyl group (such as malonate esters or ethyl cyanoacetate). The reaction leads to the formation of α,β-unsaturated carbonyl compounds.
PATH: PHARMD/PHARMD NOTES/ PHARMD FIRST YEAR NOTES/ ORGANIC CHEMISTRY/ PHARMACEUTICAL ORGANIC CHEMISTRY/ KNOEVENAGEL REACTION.