The heart’s rhythm is crucial for its proper functioning. However, certain conditions can disrupt the normal electrical activity of the heart, leading to irregular heart rhythms known as arrhythmias. Anti-arrhythmic drugs play a vital role in managing these abnormal heart rhythms and restoring the heart’s regular rhythm. In this article, we will explore the pharmacology of anti-arrhythmic drugs, their mechanisms of action, different classes of drugs, and considerations in their usage.