Ophthalmic preparations in the form of semi-solids are specialized pharmaceutical formulations used for ocular administration. They play a crucial role in the treatment of various eye conditions, such as infections, inflammation, and dryness. In this article, we will explore the introduction and classification of ophthalmic preparations, factors affecting absorption, the anatomy of the skin, packaging, storage, and labeling. We will also discuss different types of ointment bases, the preparation of ointments, types of jellies, formulation techniques for jellies, and suppositories used in ophthalmic applications.