8. MULTI-COMPARTMENT MODELS
Some drugs do not distribute instantly throughout the body. Instead, they move into different tissues at different speeds. For such drugs, the one-compartment model is not enough. This is where…
9. MULTIPLE DOSAGE REGIMENS
Most medications are not given as a single dose. They are administered repeatedly at fixed intervals to maintain consistent therapeutic levels. This is known as a multiple dosage regimen. Understanding…
10. NON-LINEAR PHARMACOKINETICS
Most drugs follow linear pharmacokinetics, where the drug concentration increases in direct proportion to the dose. However, some drugs behave differently and show non-linear pharmacokinetics. In this case, small changes…
11. NON-COMPARTMENTAL PHARMACOKINETICS
Non-compartmental pharmacokinetics (NCA) is a simple and practical method used to describe how a drug moves through the body without assuming any specific compartment model. Instead of dividing the body…
12. BIOAVAILABILITY AND BIOEQUIVALENCE
Bioavailability and bioequivalence are two core concepts of biopharmaceutics and regulatory science. They help determine how much of a drug reaches systemic circulation and whether two drug products behave the…