Peptic ulcer disease (PUD) is a prevalent gastrointestinal condition that affects millions of people worldwide. It is characterized by the formation of open sores, known as ulcers, in the lining of the stomach or the upper part of the small intestine. In this article, we will delve into the etiopathogenesis of peptic ulcer disease, exploring the factors that contribute to its development, and discuss the various pharmacotherapy options available for its treatment.