Dehydrohalogenation of alkyl halides: 1,2 elimination, kinetics, E2 and E1 mechanism, elimination via carbocation, evidence for E2 mechanism, absence of rearrangement isotope effect, absence hydrogen exchange, the element effect, orientation and reactivity, E2 versus E1, elimination versus substitution,
dehydration of alcohol, ease of dehydration, acid catalysis, reversibility, orientation.
PATH: PHARMD/PHARMD NOTES/ PHARMD FIRST YEAR NOTES/ ORGANIC CHEMISTRY/ PHARMACEUTICAL ORGANIC CHEMISTRY/ EVIDENCE FOR E2 MECHANISM, ABSENCE OF REARRANGEMENT ISOTOPE EFFECT, ABSENCE HYDROGEN EXCHANGE, THE ELEMENT EFFECT, ORIENTATION AND REACTIVITY.