A pro-drug is a chemically changed inert precursor of the drug that on biotransformation liberates the pharmacologically energetic determine compound.

A pro-drug is likewise known as as pro-agent, bioreversible spinoff or latentiated drug. The layout of pro-drug technique is likewise known as as drug latentiation.


1. It must now no longer have intrinsic pharmacologic activity.

2. Drug and the service linkage have to be cleared in vivo.

3. The metabolic fragments, other than the energetic drug, must be nontoxic.

4. It must hastily transform, chemically or enzymatically, into the energetic shape in which desired.

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