The Hofmann rearrangement is a chemical reaction that involves the conversion of primary amides (RCO-NH2) into primary amines (RNH2) with one fewer carbon atom. It is named after the German chemist August Wilhelm von Hofmann, who first described this rearrangement.
PATH: PHARMD/PHARMD NOTES/ PHARMD FIRST YEAR NOTES/ ORGANIC CHEMISTRY/ PHARMACEUTICAL ORGANIC CHEMISTRY/ HOFMANN REARRANGEMENT.