Fries rearrangement is a chemical reaction that involves the rearrangement of an ester with an aryl group attached to an adjacent carbon atom. It was discovered by the German chemist Karl Theophil Fries in the late 19th century. The Fries rearrangement is a sigmatropic rearrangement reaction that leads to the migration of the aryl group from one carbon atom to another.
PATH: PHARMD/PHARMD NOTES/ PHARMD FIRST YEAR NOTES/ ORGANIC CHEMISTRY/ PHARMACEUTICAL ORGANIC CHEMISTRY/FRIES REARRANGEMENT.