Endocarditis is a serious infection of the endocardium, which is the inner lining of the heart chambers and heart valves. It is typically caused by bacterial or, less commonly, fungal infections. Endocarditis can lead to severe complications and requires prompt diagnosis and appropriate treatment. In this article, we will explore the etiopathogenesis, or the origin and development of the disease, as well as the pharmacotherapy options for endocarditis.